The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis
Identifieur interne : 012940 ( Main/Exploration ); précédent : 012939; suivant : 012941The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis
Auteurs : Christian Sm Helker [Allemagne] ; Annika Schuermann [Allemagne] ; Cathrin Pollmann [Allemagne] ; Serene C. Chng [Singapour] ; Friedemann Kiefer [Allemagne] ; Bruno Reversade [Singapour] ; Wiebke Herzog [Allemagne]Source :
- eLife [ 2050-084X ] ; ????.
Abstract
A key step in the de novo formation of the embryonic vasculature is the migration of endothelial precursors, the angioblasts, to the position of the future vessels. To form the first axial vessels, angioblasts migrate towards the midline and coalesce underneath the notochord. Vascular endothelial growth factor has been proposed to serve as a chemoattractant for the angioblasts and to regulate this medial migration. Here we challenge this model and instead demonstrate that angioblasts rely on their intrinsic expression of Apelin receptors (Aplr, APJ) for their migration to the midline. We further show that during this angioblast migration Apelin receptor signaling is mainly triggered by the recently discovered ligand Elabela (Ela). As neither of the ligands Ela or Apelin (Apln) nor their receptors have previously been implicated in regulating angioblast migration, we hereby provide a novel mechanism for regulating vasculogenesis, with direct relevance to physiological and pathological angiogenesis.
Url:
DOI: 10.7554/eLife.06726
PubMed: 26017639
PubMed Central: 4468421
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004679
- to stream Pmc, to step Curation: 004678
- to stream Pmc, to step Checkpoint: 004C26
- to stream Ncbi, to step Merge: 007428
- to stream Ncbi, to step Curation: 007428
- to stream Ncbi, to step Checkpoint: 007428
- to stream Main, to step Merge: 013B56
- to stream Main, to step Curation: 012940
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis</title><author><name sortKey="Helker, Christian Sm" sort="Helker, Christian Sm" uniqKey="Helker C" first="Christian Sm" last="Helker">Christian Sm Helker</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>University of Muenster</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schuermann, Annika" sort="Schuermann, Annika" uniqKey="Schuermann A" first="Annika" last="Schuermann">Annika Schuermann</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>University of Muenster</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pollmann, Cathrin" sort="Pollmann, Cathrin" uniqKey="Pollmann C" first="Cathrin" last="Pollmann">Cathrin Pollmann</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Max Planck Institute for Molecular Biomedicine</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chng, Serene C" sort="Chng, Serene C" uniqKey="Chng S" first="Serene C" last="Chng">Serene C. Chng</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="dept">Institute of Medical Biology, Human Genetics and Embryology Laboratory</institution>,<institution>A*STAR</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kiefer, Friedemann" sort="Kiefer, Friedemann" uniqKey="Kiefer F" first="Friedemann" last="Kiefer">Friedemann Kiefer</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Max Planck Institute for Molecular Biomedicine</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Cells-in-Motion Cluster of Excellence</institution>,<institution>University of Muenster</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reversade, Bruno" sort="Reversade, Bruno" uniqKey="Reversade B" first="Bruno" last="Reversade">Bruno Reversade</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="dept">Institute of Medical Biology, Human Genetics and Embryology Laboratory</institution>,<institution>A*STAR</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herzog, Wiebke" sort="Herzog, Wiebke" uniqKey="Herzog W" first="Wiebke" last="Herzog">Wiebke Herzog</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>University of Muenster</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Max Planck Institute for Molecular Biomedicine</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Cells-in-Motion Cluster of Excellence</institution>,<institution>University of Muenster</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26017639</idno><idno type="pmc">4468421</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468421</idno><idno type="RBID">PMC:4468421</idno><idno type="doi">10.7554/eLife.06726</idno><date when="????">????</date><idno type="wicri:Area/Pmc/Corpus">004679</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004679</idno><idno type="wicri:Area/Pmc/Curation">004678</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004678</idno><idno type="wicri:Area/Pmc/Checkpoint">004C26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">004C26</idno><idno type="wicri:Area/Ncbi/Merge">007428</idno><idno type="wicri:Area/Ncbi/Curation">007428</idno><idno type="wicri:Area/Ncbi/Checkpoint">007428</idno><idno type="wicri:Area/Main/Merge">013B56</idno><idno type="wicri:Area/Main/Curation">012940</idno><idno type="wicri:Area/Main/Exploration">012940</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis</title><author><name sortKey="Helker, Christian Sm" sort="Helker, Christian Sm" uniqKey="Helker C" first="Christian Sm" last="Helker">Christian Sm Helker</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>University of Muenster</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schuermann, Annika" sort="Schuermann, Annika" uniqKey="Schuermann A" first="Annika" last="Schuermann">Annika Schuermann</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>University of Muenster</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pollmann, Cathrin" sort="Pollmann, Cathrin" uniqKey="Pollmann C" first="Cathrin" last="Pollmann">Cathrin Pollmann</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Max Planck Institute for Molecular Biomedicine</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chng, Serene C" sort="Chng, Serene C" uniqKey="Chng S" first="Serene C" last="Chng">Serene C. Chng</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="dept">Institute of Medical Biology, Human Genetics and Embryology Laboratory</institution>,<institution>A*STAR</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kiefer, Friedemann" sort="Kiefer, Friedemann" uniqKey="Kiefer F" first="Friedemann" last="Kiefer">Friedemann Kiefer</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Max Planck Institute for Molecular Biomedicine</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Cells-in-Motion Cluster of Excellence</institution>,<institution>University of Muenster</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reversade, Bruno" sort="Reversade, Bruno" uniqKey="Reversade B" first="Bruno" last="Reversade">Bruno Reversade</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="dept">Institute of Medical Biology, Human Genetics and Embryology Laboratory</institution>,<institution>A*STAR</institution>,<addr-line>Singapore</addr-line>,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Herzog, Wiebke" sort="Herzog, Wiebke" uniqKey="Herzog W" first="Wiebke" last="Herzog">Wiebke Herzog</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>University of Muenster</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Max Planck Institute for Molecular Biomedicine</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Cells-in-Motion Cluster of Excellence</institution>,<institution>University of Muenster</institution>,<addr-line>Muenster</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">eLife</title><idno type="eISSN">2050-084X</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A key step in the de novo formation of the embryonic vasculature is the migration of endothelial precursors, the angioblasts, to the position of the future vessels. To form the first axial vessels, angioblasts migrate towards the midline and coalesce underneath the notochord. Vascular endothelial growth factor has been proposed to serve as a chemoattractant for the angioblasts and to regulate this medial migration. Here we challenge this model and instead demonstrate that angioblasts rely on their intrinsic expression of Apelin receptors (Aplr, APJ) for their migration to the midline. We further show that during this angioblast migration Apelin receptor signaling is mainly triggered by the recently discovered ligand Elabela (Ela). As neither of the ligands Ela or Apelin (Apln) nor their receptors have previously been implicated in regulating angioblast migration, we hereby provide a novel mechanism for regulating vasculogenesis, with direct relevance to physiological and pathological angiogenesis.</p><p><bold>DOI:</bold><ext-link ext-link-type="doi" xlink:href="10.7554/eLife.06726.001">http://dx.doi.org/10.7554/eLife.06726.001</ext-link></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bussmann, J" uniqKey="Bussmann J">J Bussmann</name></author><author><name sortKey="Bos, Fl" uniqKey="Bos F">FL Bos</name></author><author><name sortKey="Urasaki, A" uniqKey="Urasaki A">A Urasaki</name></author><author><name sortKey="Kawakami, K" uniqKey="Kawakami K">K Kawakami</name></author><author><name sortKey="Duckers, Hj" uniqKey="Duckers H">HJ Duckers</name></author><author><name sortKey="Schulte Merker, S" uniqKey="Schulte Merker S">S Schulte-Merker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cermak, T" uniqKey="Cermak T">T Cermak</name></author><author><name sortKey="Doyle, El" uniqKey="Doyle E">EL Doyle</name></author><author><name sortKey="Christian, M" uniqKey="Christian M">M Christian</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Schmidt, C" uniqKey="Schmidt C">C Schmidt</name></author><author><name sortKey="Baller, Ja" uniqKey="Baller J">JA Baller</name></author><author><name sortKey="Somia, Nv" uniqKey="Somia N">NV Somia</name></author><author><name sortKey="Bogdanove, Aj" uniqKey="Bogdanove A">AJ Bogdanove</name></author><author><name sortKey="Voytas, Df" uniqKey="Voytas D">DF Voytas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charo, Dn" uniqKey="Charo D">DN Charo</name></author><author><name sortKey="Ho, M" uniqKey="Ho M">M Ho</name></author><author><name sortKey="Fajardo, G" uniqKey="Fajardo G">G Fajardo</name></author><author><name sortKey="Kawana, M" uniqKey="Kawana M">M Kawana</name></author><author><name sortKey="Kundu, Rk" uniqKey="Kundu R">RK Kundu</name></author><author><name sortKey="Sheikh, Ay" uniqKey="Sheikh A">AY Sheikh</name></author><author><name sortKey="Finsterbach, Tp" uniqKey="Finsterbach T">TP Finsterbach</name></author><author><name sortKey="Leeper, Nj" uniqKey="Leeper N">NJ Leeper</name></author><author><name sortKey="Ernst, Kv" uniqKey="Ernst K">KV Ernst</name></author><author><name sortKey="Chen, Mm" uniqKey="Chen M">MM Chen</name></author><author><name sortKey="Ho, Yd" uniqKey="Ho Y">YD Ho</name></author><author><name sortKey="Chun, Hj" uniqKey="Chun H">HJ Chun</name></author><author><name sortKey="Bernstein, D" uniqKey="Bernstein D">D Bernstein</name></author><author><name sortKey="Ashley, Ea" uniqKey="Ashley E">EA Ashley</name></author><author><name sortKey="Quertermous, T" uniqKey="Quertermous T">T Quertermous</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chng, Sc" uniqKey="Chng S">SC Chng</name></author><author><name sortKey="Ho, L" uniqKey="Ho L">L Ho</name></author><author><name sortKey="Tian, J" uniqKey="Tian J">J Tian</name></author><author><name sortKey="Reversade, B" uniqKey="Reversade B">B Reversade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cleaver, O" uniqKey="Cleaver O">O Cleaver</name></author><author><name sortKey="Krieg, Pa" uniqKey="Krieg P">PA Krieg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coultas, L" uniqKey="Coultas L">L Coultas</name></author><author><name sortKey="Chawengsaksophak, K" uniqKey="Chawengsaksophak K">K Chawengsaksophak</name></author><author><name sortKey="Rossant, J" uniqKey="Rossant J">J Rossant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrara, N" uniqKey="Ferrara N">N Ferrara</name></author><author><name sortKey="Carver Moore, K" uniqKey="Carver Moore K">K Carver-Moore</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Dowd, M" uniqKey="Dowd M">M Dowd</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="O Shea, Ks" uniqKey="O Shea K">KS O'Shea</name></author><author><name sortKey="Powell Braxton, L" uniqKey="Powell Braxton L">L Powell-Braxton</name></author><author><name sortKey="Hillan, Kj" uniqKey="Hillan K">KJ Hillan</name></author><author><name sortKey="Moore, Mw" uniqKey="Moore M">MW Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouquet, B" uniqKey="Fouquet B">B Fouquet</name></author><author><name sortKey="Weinstein, Bm" uniqKey="Weinstein B">BM Weinstein</name></author><author><name sortKey="Serluca, Fc" uniqKey="Serluca F">FC Serluca</name></author><author><name sortKey="Fishman, Mc" uniqKey="Fishman M">MC Fishman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gordon, K" uniqKey="Gordon K">K Gordon</name></author><author><name sortKey="Schulte, D" uniqKey="Schulte D">D Schulte</name></author><author><name sortKey="Brice, G" uniqKey="Brice G">G Brice</name></author><author><name sortKey="Simpson, Ma" uniqKey="Simpson M">MA Simpson</name></author><author><name sortKey="Roukens, Mg" uniqKey="Roukens M">MG Roukens</name></author><author><name sortKey="Van Impel, A" uniqKey="Van Impel A">A van Impel</name></author><author><name sortKey="Connell, F" uniqKey="Connell F">F Connell</name></author><author><name sortKey="Kalidas, K" uniqKey="Kalidas K">K Kalidas</name></author><author><name sortKey="Jeffery, S" uniqKey="Jeffery S">S Jeffery</name></author><author><name sortKey="Mortimer, Ps" uniqKey="Mortimer P">PS Mortimer</name></author><author><name sortKey="Mansour, S" uniqKey="Mansour S">S Mansour</name></author><author><name sortKey="Schulte Merker, S" uniqKey="Schulte Merker S">S Schulte-Merker</name></author><author><name sortKey="Ostergaard, P" uniqKey="Ostergaard P">P Ostergaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gore, Av" uniqKey="Gore A">AV Gore</name></author><author><name sortKey="Monzo, K" uniqKey="Monzo K">K Monzo</name></author><author><name sortKey="Cha, Yr" uniqKey="Cha Y">YR Cha</name></author><author><name sortKey="Pan, W" uniqKey="Pan W">W Pan</name></author><author><name sortKey="Weinstein, Bm" uniqKey="Weinstein B">BM Weinstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halpern, Me" uniqKey="Halpern M">ME Halpern</name></author><author><name sortKey="Ho, Rk" uniqKey="Ho R">RK Ho</name></author><author><name sortKey="Walker, C" uniqKey="Walker C">C Walker</name></author><author><name sortKey="Kimmel, Cb" uniqKey="Kimmel C">CB Kimmel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Helker, Cs" uniqKey="Helker C">CS Helker</name></author><author><name sortKey="Schuermann, A" uniqKey="Schuermann A">A Schuermann</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Zeuschner, D" uniqKey="Zeuschner D">D Zeuschner</name></author><author><name sortKey="Belting, Hg" uniqKey="Belting H">HG Belting</name></author><author><name sortKey="Affolter, M" uniqKey="Affolter M">M Affolter</name></author><author><name sortKey="Schulte Merker, S" uniqKey="Schulte Merker S">S Schulte-Merker</name></author><author><name sortKey="Herzog, W" uniqKey="Herzog W">W Herzog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hesselson, D" uniqKey="Hesselson D">D Hesselson</name></author><author><name sortKey="Anderson, Rm" uniqKey="Anderson R">RM Anderson</name></author><author><name sortKey="Beinat, M" uniqKey="Beinat M">M Beinat</name></author><author><name sortKey="Stainier, Dy" uniqKey="Stainier D">DY Stainier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hogan, Bm" uniqKey="Hogan B">BM Hogan</name></author><author><name sortKey="Bos, Fl" uniqKey="Bos F">FL Bos</name></author><author><name sortKey="Bussmann, J" uniqKey="Bussmann J">J Bussmann</name></author><author><name sortKey="Witte, M" uniqKey="Witte M">M Witte</name></author><author><name sortKey="Chi, Nc" uniqKey="Chi N">NC Chi</name></author><author><name sortKey="Duckers, Hj" uniqKey="Duckers H">HJ Duckers</name></author><author><name sortKey="Schulte Merker, S" uniqKey="Schulte Merker S">S Schulte-Merker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hwang, Wy" uniqKey="Hwang W">WY Hwang</name></author><author><name sortKey="Fu, Yf" uniqKey="Fu Y">YF Fu</name></author><author><name sortKey="Reyon, D" uniqKey="Reyon D">D Reyon</name></author><author><name sortKey="Maeder, Ml" uniqKey="Maeder M">ML Maeder</name></author><author><name sortKey="Tsai, Sq" uniqKey="Tsai S">SQ Tsai</name></author><author><name sortKey="Sander, Jd" uniqKey="Sander J">JD Sander</name></author><author><name sortKey="Peterson, Rt" uniqKey="Peterson R">RT Peterson</name></author><author><name sortKey="Yeh, Jrj" uniqKey="Yeh J">JRJ Yeh</name></author><author><name sortKey="Joung, Jk" uniqKey="Joung J">JK Joung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jao, Le" uniqKey="Jao L">LE Jao</name></author><author><name sortKey="Wente, Sr" uniqKey="Wente S">SR Wente</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawakami, K" uniqKey="Kawakami K">K Kawakami</name></author><author><name sortKey="Takeda, H" uniqKey="Takeda H">H Takeda</name></author><author><name sortKey="Kawakami, N" uniqKey="Kawakami N">N Kawakami</name></author><author><name sortKey="Kobayashi, M" uniqKey="Kobayashi M">M Kobayashi</name></author><author><name sortKey="Matsuda, N" uniqKey="Matsuda N">N Matsuda</name></author><author><name sortKey="Mishina, M" uniqKey="Mishina M">M Mishina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kimmel, Cb" uniqKey="Kimmel C">CB Kimmel</name></author><author><name sortKey="Ballard, Ww" uniqKey="Ballard W">WW Ballard</name></author><author><name sortKey="Kimmel, Sr" uniqKey="Kimmel S">SR Kimmel</name></author><author><name sortKey="Ullmann, B" uniqKey="Ullmann B">B Ullmann</name></author><author><name sortKey="Schilling, Tf" uniqKey="Schilling T">TF Schilling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larson, Jd" uniqKey="Larson J">JD Larson</name></author><author><name sortKey="Wadman, Sa" uniqKey="Wadman S">SA Wadman</name></author><author><name sortKey="Chen, E" uniqKey="Chen E">E Chen</name></author><author><name sortKey="Kerley, L" uniqKey="Kerley L">L Kerley</name></author><author><name sortKey="Clark, Kj" uniqKey="Clark K">KJ Clark</name></author><author><name sortKey="Eide, M" uniqKey="Eide M">M Eide</name></author><author><name sortKey="Lippert, S" uniqKey="Lippert S">S Lippert</name></author><author><name sortKey="Nasevicius, A" uniqKey="Nasevicius A">A Nasevicius</name></author><author><name sortKey="Ekker, Sc" uniqKey="Ekker S">SC Ekker</name></author><author><name sortKey="Hackett, Pb" uniqKey="Hackett P">PB Hackett</name></author><author><name sortKey="Essner, Jj" uniqKey="Essner J">JJ Essner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lawson, Nd" uniqKey="Lawson N">ND Lawson</name></author><author><name sortKey="Vogel, Am" uniqKey="Vogel A">AM Vogel</name></author><author><name sortKey="Weinstein, Bm" uniqKey="Weinstein B">BM Weinstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lawson, Nd" uniqKey="Lawson N">ND Lawson</name></author><author><name sortKey="Weinstein, Bm" uniqKey="Weinstein B">BM Weinstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nasevicius, A" uniqKey="Nasevicius A">A Nasevicius</name></author><author><name sortKey="Ekker, Sc" uniqKey="Ekker S">SC Ekker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicoli, S" uniqKey="Nicoli S">S Nicoli</name></author><author><name sortKey="Tobia, C" uniqKey="Tobia C">C Tobia</name></author><author><name sortKey="Gualandi, L" uniqKey="Gualandi L">L Gualandi</name></author><author><name sortKey="De Sena, G" uniqKey="De Sena G">G De Sena</name></author><author><name sortKey="Presta, M" uniqKey="Presta M">M Presta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ober, Ea" uniqKey="Ober E">EA Ober</name></author><author><name sortKey="Olofsson, B" uniqKey="Olofsson B">B Olofsson</name></author><author><name sortKey="Makinen, T" uniqKey="Makinen T">T Makinen</name></author><author><name sortKey="Jin, Sw" uniqKey="Jin S">SW Jin</name></author><author><name sortKey="Shoji, W" uniqKey="Shoji W">W Shoji</name></author><author><name sortKey="Koh, Gy" uniqKey="Koh G">GY Koh</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Stainier, Dy" uniqKey="Stainier D">DY Stainier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Odenthal, J" uniqKey="Odenthal J">J Odenthal</name></author><author><name sortKey="Haffter, P" uniqKey="Haffter P">P Haffter</name></author><author><name sortKey="Vogelsang, E" uniqKey="Vogelsang E">E Vogelsang</name></author><author><name sortKey="Brand, M" uniqKey="Brand M">M Brand</name></author><author><name sortKey="Van Eeden, Fj" uniqKey="Van Eeden F">FJ van Eeden</name></author><author><name sortKey="Furutani Seiki, M" uniqKey="Furutani Seiki M">M Furutani-Seiki</name></author><author><name sortKey="Granato, M" uniqKey="Granato M">M Granato</name></author><author><name sortKey="Hammerschmidt, M" uniqKey="Hammerschmidt M">M Hammerschmidt</name></author><author><name sortKey="Heisenberg, Cp" uniqKey="Heisenberg C">CP Heisenberg</name></author><author><name sortKey="Jiang, Yj" uniqKey="Jiang Y">YJ Jiang</name></author><author><name sortKey="Kane, Da" uniqKey="Kane D">DA Kane</name></author><author><name sortKey="Kelsh, Rn" uniqKey="Kelsh R">RN Kelsh</name></author><author><name sortKey="Mullins, Mc" uniqKey="Mullins M">MC Mullins</name></author><author><name sortKey="Warga, Rm" uniqKey="Warga R">RM Warga</name></author><author><name sortKey="Allende, Ml" uniqKey="Allende M">ML Allende</name></author><author><name sortKey="Weinberg, Es" uniqKey="Weinberg E">ES Weinberg</name></author><author><name sortKey="Nusslein Volhard, C" uniqKey="Nusslein Volhard C">C Nüsslein-Volhard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pauli, A" uniqKey="Pauli A">A Pauli</name></author><author><name sortKey="Norris, Ml" uniqKey="Norris M">ML Norris</name></author><author><name sortKey="Valen, E" uniqKey="Valen E">E Valen</name></author><author><name sortKey="Chew, Gl" uniqKey="Chew G">GL Chew</name></author><author><name sortKey="Gagnon, Ja" uniqKey="Gagnon J">JA Gagnon</name></author><author><name sortKey="Zimmerman, S" uniqKey="Zimmerman S">S Zimmerman</name></author><author><name sortKey="Mitchell, A" uniqKey="Mitchell A">A Mitchell</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name></author><author><name sortKey="Dubrulle, J" uniqKey="Dubrulle J">J Dubrulle</name></author><author><name sortKey="Reyon, D" uniqKey="Reyon D">D Reyon</name></author><author><name sortKey="Tsai, Sq" uniqKey="Tsai S">SQ Tsai</name></author><author><name sortKey="Joung, Jk" uniqKey="Joung J">JK Joung</name></author><author><name sortKey="Saghatelian, A" uniqKey="Saghatelian A">A Saghatelian</name></author><author><name sortKey="Schier, Af" uniqKey="Schier A">AF Schier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santoro, Mm" uniqKey="Santoro M">MM Santoro</name></author><author><name sortKey="Samuel, T" uniqKey="Samuel T">T Samuel</name></author><author><name sortKey="Mitchell, T" uniqKey="Mitchell T">T Mitchell</name></author><author><name sortKey="Reed, Jc" uniqKey="Reed J">JC Reed</name></author><author><name sortKey="Stainier, Dy" uniqKey="Stainier D">DY Stainier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scott, Ic" uniqKey="Scott I">IC Scott</name></author><author><name sortKey="Masri, B" uniqKey="Masri B">B Masri</name></author><author><name sortKey="D Amico, La" uniqKey="D Amico L">LA D'Amico</name></author><author><name sortKey="Jin, Sw" uniqKey="Jin S">SW Jin</name></author><author><name sortKey="Jungblut, B" uniqKey="Jungblut B">B Jungblut</name></author><author><name sortKey="Wehman, Am" uniqKey="Wehman A">AM Wehman</name></author><author><name sortKey="Baier, H" uniqKey="Baier H">H Baier</name></author><author><name sortKey="Audigier, Y" uniqKey="Audigier Y">Y Audigier</name></author><author><name sortKey="Stainier, Dy" uniqKey="Stainier D">DY Stainier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shalaby, F" uniqKey="Shalaby F">F Shalaby</name></author><author><name sortKey="Rossant, J" uniqKey="Rossant J">J Rossant</name></author><author><name sortKey="Yamaguchi, Tp" uniqKey="Yamaguchi T">TP Yamaguchi</name></author><author><name sortKey="Gertsenstein, M" uniqKey="Gertsenstein M">M Gertsenstein</name></author><author><name sortKey="Wu, Xf" uniqKey="Wu X">XF Wu</name></author><author><name sortKey="Breitman, Ml" uniqKey="Breitman M">ML Breitman</name></author><author><name sortKey="Schuh, Ac" uniqKey="Schuh A">AC Schuh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sumoy, L" uniqKey="Sumoy L">L Sumoy</name></author><author><name sortKey="Keasey, Jb" uniqKey="Keasey J">JB Keasey</name></author><author><name sortKey="Dittman, Td" uniqKey="Dittman T">TD Dittman</name></author><author><name sortKey="Kimelman, D" uniqKey="Kimelman D">D Kimelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verma, A" uniqKey="Verma A">A Verma</name></author><author><name sortKey="Bhattacharya, R" uniqKey="Bhattacharya R">R Bhattacharya</name></author><author><name sortKey="Remadevi, I" uniqKey="Remadevi I">I Remadevi</name></author><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Pramanik, K" uniqKey="Pramanik K">K Pramanik</name></author><author><name sortKey="Samant, Gv" uniqKey="Samant G">GV Samant</name></author><author><name sortKey="Horswill, M" uniqKey="Horswill M">M Horswill</name></author><author><name sortKey="Chun, Cz" uniqKey="Chun C">CZ Chun</name></author><author><name sortKey="Zhao, B" uniqKey="Zhao B">B Zhao</name></author><author><name sortKey="Wang, E" uniqKey="Wang E">E Wang</name></author><author><name sortKey="Miao, Rq" uniqKey="Miao R">RQ Miao</name></author><author><name sortKey="Mukhopadhyay, D" uniqKey="Mukhopadhyay D">D Mukhopadhyay</name></author><author><name sortKey="Ramchandran, R" uniqKey="Ramchandran R">R Ramchandran</name></author><author><name sortKey="Wilkinson, Ga" uniqKey="Wilkinson G">GA Wilkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westerfield, M" uniqKey="Westerfield M">M Westerfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeng, Xx" uniqKey="Zeng X">XX Zeng</name></author><author><name sortKey="Wilm, Tp" uniqKey="Wilm T">TP Wilm</name></author><author><name sortKey="Sepich, Ds" uniqKey="Sepich D">DS Sepich</name></author><author><name sortKey="Solnica Krezel, L" uniqKey="Solnica Krezel L">L Solnica-Krezel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Cao, Z" uniqKey="Cao Z">Z Cao</name></author><author><name sortKey="Tian, H" uniqKey="Tian H">H Tian</name></author><author><name sortKey="Shen, G" uniqKey="Shen G">G Shen</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name></author><author><name sortKey="Xie, H" uniqKey="Xie H">H Xie</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Zhao, C" uniqKey="Zhao C">C Zhao</name></author><author><name sortKey="Deng, S" uniqKey="Deng S">S Deng</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Zheng, R" uniqKey="Zheng R">R Zheng</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Zhang, N" uniqKey="Zhang N">N Zhang</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Dai, L" uniqKey="Dai L">L Dai</name></author><author><name sortKey="Shi, S" uniqKey="Shi S">S Shi</name></author><author><name sortKey="Cheng, L" uniqKey="Cheng L">L Cheng</name></author><author><name sortKey="Pan, Y" uniqKey="Pan Y">Y Pan</name></author><author><name sortKey="Feng, S" uniqKey="Feng S">S Feng</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Deng, H" uniqKey="Deng H">H Deng</name></author><author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name></author><author><name sortKey="Wei, Y" uniqKey="Wei Y">Y Wei</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Singapour</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Helker, Christian Sm" sort="Helker, Christian Sm" uniqKey="Helker C" first="Christian Sm" last="Helker">Christian Sm Helker</name></noRegion><name sortKey="Herzog, Wiebke" sort="Herzog, Wiebke" uniqKey="Herzog W" first="Wiebke" last="Herzog">Wiebke Herzog</name><name sortKey="Herzog, Wiebke" sort="Herzog, Wiebke" uniqKey="Herzog W" first="Wiebke" last="Herzog">Wiebke Herzog</name><name sortKey="Herzog, Wiebke" sort="Herzog, Wiebke" uniqKey="Herzog W" first="Wiebke" last="Herzog">Wiebke Herzog</name><name sortKey="Kiefer, Friedemann" sort="Kiefer, Friedemann" uniqKey="Kiefer F" first="Friedemann" last="Kiefer">Friedemann Kiefer</name><name sortKey="Kiefer, Friedemann" sort="Kiefer, Friedemann" uniqKey="Kiefer F" first="Friedemann" last="Kiefer">Friedemann Kiefer</name><name sortKey="Pollmann, Cathrin" sort="Pollmann, Cathrin" uniqKey="Pollmann C" first="Cathrin" last="Pollmann">Cathrin Pollmann</name><name sortKey="Schuermann, Annika" sort="Schuermann, Annika" uniqKey="Schuermann A" first="Annika" last="Schuermann">Annika Schuermann</name></country><country name="Singapour"><noRegion><name sortKey="Chng, Serene C" sort="Chng, Serene C" uniqKey="Chng S" first="Serene C" last="Chng">Serene C. Chng</name></noRegion><name sortKey="Reversade, Bruno" sort="Reversade, Bruno" uniqKey="Reversade B" first="Bruno" last="Reversade">Bruno Reversade</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 012940 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 012940 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4468421
|texte= The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26017639" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |